Publications by authors named "A C Knopf"
Toward Closing the Loop in Image-to-Image Conversion in Radiotherapy: A Quality Control Tool to Predict Synthetic Computed Tomography Hounsfield Unit Accuracy.
J Imaging
December 2024
In recent years, synthetic Computed Tomography (CT) images generated from Magnetic Resonance (MR) or Cone Beam Computed Tomography (CBCT) acquisitions have been shown to be comparable to real CT images in terms of dose computation for radiotherapy simulation. However, until now, there has been no independent strategy to assess the quality of each synthetic image in the absence of ground truth. In this work, we propose a Deep Learning (DL)-based framework to predict the accuracy of synthetic CT in terms of Mean Absolute Error (MAE) without the need for a ground truth (GT).
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- The study investigates how diagnostic methods and treatments affect outcomes and survival rates in patients with pharyngeal perforations caused by medical procedures or trauma.
- A total of 36 patients were reviewed, with most being older adults (median age 73), and the majority had perforations located in the hypopharynx, which are associated with higher mortality risk.
- Results indicated that these patients had significantly higher risks of complications and mortality, especially linked to specific medical procedures like neurosurgery and transesophageal echocardiography.
Objective: This retrospective multicenter study aimed to evaluate surgical versus conservative treatment in patients with hypopharyngeal and laryngeal cancer under real world conditions.
Methods: This study included 2307 patients diagnosed with hypopharyngeal or laryngeal squamous cell carcinoma (SCC) in five German tertiary head and neck centers between 01/2004 and 12/2014. Overall, 783 patients with advanced SCC consecutively underwent laryng(opharyng)ectomy (L(P)E).
Objectives: Virtual reality (VR) appears to be a promising educational tool for otorhinolaryngology (ORL) residency training, as it allows for safe and effective practice immediate feedback and potential improvements in patient outcomes. Despite these advantages, VR has not yet been incorporated into residency training in ORL, which may be due to limited availability or validation and skepticism toward incorporation of new training methods. This study investigates whether a VR model of the temporal bone improves learning success for ORL residents in comparison to standard plastic models and whether it depends on surgeon's experience.
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- The COVID-19 pandemic has changed the spread and patterns of infectious diseases, impacting vaccination programs and overall health measures.
- A study at a tertiary university in Germany analyzed 1,728 cases of ear, nose, and throat infections from 2019 to 2023, finding a notable increase in infections like peritonsillar abscesses and acute tonsillitis in the winter of 2022.
- Unlike previous years, there was no typical summer decline in infections post-pandemic, and mononucleosis showed no significant increase, suggesting the end of certain health interventions had lasting effects.