Publications by authors named "A C KITTLESON"
Background: The insula is a heterogeneous cortical region with three cytoarchitectural subregions-agranular, dysgranular, and granular-that have distinct functional roles. Previous cross-sectional studies have shown smaller volume of all insula subregions in individuals with psychotic disorders. However, longitudinal trajectories of insula subregions in early psychosis, and the relationship between subregional volumes and relevant clinical phenomena, such as perceptual aberrations, have not been previously examined.
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- Childhood maltreatment, especially threat-related experiences, is linked to heightened expectations of environmental volatility, which may influence how beliefs are updated in individuals with schizophrenia-spectrum disorders.
- The study involved 151 participants (75 with schizophrenia-spectrum disorders and 76 controls) and employed a probabilistic learning task to assess belief updating, alongside questionnaires measuring maltreatment and paranoia levels.
- Results indicated that those with a history of threat-related maltreatment displayed greater volatility expectations, but belief updating did not significantly mediate the link between maltreatment and paranoia.
Schizophrenia is a highly heterogeneous disorder characterized by a multitude of complex and seemingly non-overlapping symptoms. The insular cortex has gained increasing attention in neuroscience and psychiatry due to its involvement in a diverse range of fundamental human experiences and behaviors. This review article provides an overview of the insula's cellular and anatomical organization, functional and structural connectivity, and functional significance.
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