XIS-Temperature: A daily spatiotemporal machine-learning model for air temperature in the contiguous United States.

The challenge of reconstructing air temperature for environmental applications is to accurately estimate past exposures even where monitoring is sparse. We present XGBoost-IDW Synthesis for air temperature (XIS-Temperature), a high-resolution machine-learning model for daily minimum, mean, and maximum air temperature, covering the contiguous US from 2003 through 2023. XIS uses remote sensing (land surface temperature and vegetation) along with a parsimonious set of additional predictors to make predictions at arbitrary points, allowing the estimation of address-level exposures.

Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure.

Ischemic heart disease is the leading cause of death worldwide. Reduced oxygen supply and myocardial hypoxia lead to tissue damage and impairment of the heart function. To the best of our knowledge, the primary functional effects of hypoxia in the multicellular model of living myocardial slices (LMSs) have not been investigated so far.

Running on Fumes: An Analysis of Fine Particulate Matter's Impact on Finish Times in Nine Major US Marathons, 2003-2019.

Background: Under controlled conditions and in some observational studies of runners, airborne fine particulate matter smaller than 2.5 microns in diameter (PM) is associated with exercise performance decrements.

Objective: To assess the association between event-day fine particulate matter air pollution (PM) and marathon finish times.

Impact of metabolism-disrupting chemicals and folic acid supplementation on liver injury and steatosis in mother-child pairs.

Background And Aims: Scarce knowledge about the impact of metabolism-disrupting chemicals (MDCs) on steatotic liver disease limits opportunities for intervention. We evaluated pregnancy MDC-mixture associations with liver outcomes, and effect modification by folic acid (FA) supplementation in mother-child pairs.

Methods: We studied ∼200 mother-child pairs from the Mexican PROGRESS cohort, with measured 43 MDCs during pregnancy (estimated air pollutants, blood/urine metals or metalloids, urine high- and low-molecular-weight phthalate [HMWPs, LMWPs] and organophosphate-pesticide [OP] metabolites), and serum liver enzymes (ALT, AST) at ∼9 years post-parturition.

Windows of Susceptibility to Air Pollution During and Surrounding Pregnancy in Relation to Longitudinal Maternal Measures of Adiposity and Lipid Profiles.

Pregnancy is a critical window for long-term metabolic programming of fetal effects stemming from airborne particulate matter ≤2.5μm (PM ) exposure. Yet, little is known about long-term metabolic effects of PM exposure during and surrounding pregnancy in mothers.