Bis-zirconocenes Generated from Weinreb 2-Allylaminoacetamides as Key Intermediates for a Diastereoselective Approach to 2- and 6-Substituted-3-Aminopiperidines.

The synthesis of 2- and 6-substituted-3-aminopiperidines from Weinreb amides containing an allylamino fragment is reported. Involving the simultaneous hydrozirconation of the C═C and the C═O bonds, the cyclization was promoted by the BF-mediated generation of an iminium. Proven to be highly diastereoselective, the sequence can be applied to diversely substituted unsaturated Weinreb amides and valorized through the preparation of bicyclic heterocycles.

evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future applications.

Introduction: Peripheral nerve injuries, resulting from trauma or medical interventions, present significant clinical challenges due to their severe physiological and functional impacts. Despite various therapeutic approaches, optimal methods for promoting nerve regeneration remain difficult to obtain. This study is a preliminary step towards the future use of chitosan nerve guide conduits combined with human dental pulp stem cells and their conditioned media to promote nerve regrowth in a rat model with severe sciatic nerve damage.

Bacterial DNA in patients with ruptured intracranial aneurysms: Investigating the potential role of periodontal and gut microbiota.

Background And Objectives: Chronic periodontal bacterial infections and disruptions in gut microbiota are responsible for systemic inflammation, which may contribute to the rupture of intracranial aneurysm. This study aimed to assess the presence of bacterial DNA from Fusobacterium nucleatum and Escherichia coli within arterial tissues of intracranial aneurysms.

Methodology: A comprehensive cross-sectional study was conducted, applying stringent inclusion and exclusion criteria to carefully select the study population from patients admitted to the Division of Neurosurgery at Hospital das Clínicas, University of São Paulo.

Detection of Bagaza Virus in Europe: A Scoping Review.

The Bagaza virus (BAGV) belongs to the genus (Ntaya serocomplex) and emerged in Europe, Spain, in 2010. The natural transmission cycle of this virus is perpetuated by spp. mosquitoes and viraemic birds.

in Bat Species in Portugal.

Histoplasmosis, caused by the fungus , poses health risks to various mammals, including humans. Bats are primary wild carriers of , playing a crucial role in its epidemiology. However, fecal shedding in Europe remains poorly studied, with no data available for Portugal.