Publications by authors named "A C Hendricks"
Purpose: The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study investigated the variability in treatment recommendations for localized STS across different German-speaking tertiary sarcoma centers.
View Article and Find Full Text PDFIn neurons, patterns of different microtubule types are essential for neurite extension and nucleokinesis. Cellular model systems such as rodent primary cultures and induced pluripotent stem cells (iPSC)-derived neurons have provided key insights into how these patterns are created and maintained through the action of microtubule-associated proteins, motor proteins, and regulatory enzymes. iPSC-derived models show tremendous promise but lack benchmarking and validation relative to rodent primary cultures.
View Article and Find Full Text PDFMethods involving summary statistics in genetics can be quite powerful but can be limited in utility. For instance, many post-hoc analyses of disease studies require case and control allele frequencies (AFs), which are not always published. We present two frameworks to derive case and control AFs from GWAS summary statistics using the odds ratio, case and control sample sizes, and either the total (case and control aggregated) AF or standard error (SE).
View Article and Find Full Text PDFArticle Synopsis
- Chronic hand eczema (CHE) is a common skin condition that is hard to treat, but the drug dupilumab, known for treating atopic dermatitis, shows promise for CHE as well.
- A review of 22 studies involving 374 patients revealed that 80.3% experienced partial or complete improvement within 4-16 weeks of starting dupilumab, with effects often lasting beyond the studies.
- While dupilumab proved effective for various CHE subtypes, it was particularly successful for dyshidrotic and vesicular forms, but less so for hyperkeratotic eczema; the most common side effects included conjunctivitis and mild skin reactions.
Fungal dysbiosis following antibacterial monotherapy in canine otitis externa.
J Small Anim Pract
November 2024
Article Synopsis
- The study aimed to investigate whether treating refractory bacterial otitis in dogs with specific topical antibiotics leads to an increase in yeast overgrowth, particularly Malassezia.
- Twenty-nine dogs were treated with either fluoroquinolone or a combination of piperacillin and tazobactam, and ear swabs were taken to measure bacterial and yeast levels before and after treatment.
- Results showed a significant reduction in bacterial infections after treatment, but a notable increase in yeast (especially in dogs treated with piperacillin/tazobactam), highlighting the importance of monitoring for yeast overgrowth during antibacterial treatment.