Publications by authors named "A C H Geurts"
Rat models have been a major model for studying complex disease mechanisms, behavioral phenotypes, environmental factors, and for drug development and discovery. Inbred rat strains control for genetic background and allow for repeated, reproducible, cellular and whole animal phenotyping. The Hybrid Rat Diversity Panel (HRDP) was designed to be a powerful panel of inbred rats with genomic, physiological, and behavioral data to serve as a resource for systems genetics.
View Article and Find Full Text PDFBackground: Hypertension or elevated blood pressure (BP) is a worldwide clinical challenge and the leading primary risk factor for kidney dysfunctions, heart failure, and cerebrovascular disease. The kidney is a central regulator of BP by maintaining sodium-water balance. Multiple genome-wide association studies revealed that BP is a heritable quantitative trait, modulated by several genetic, epigenetic, and environmental factors.
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- The study investigates a specific variant of adenylate cyclase 3 (Adcy3) linked to obesity and depression in rats, analyzing its impact on body weight and behavior.
- Researchers created knockout rats with mutations in the Adcy3 gene and observed their responses to a high-fat diet, noting differences in fat mass, food intake, and emotional behavior between genders.
- Findings suggest that the Adcy3 variant affects signaling pathways related to metabolism and emotional responses, indicating a potential connection between obesity and major depressive disorder, influenced by sex differences.
Arterioles are small blood vessels located just upstream of capillaries in nearly all tissues. The constriction and dilation of arterioles regulate tissue perfusion and are primary determinants of systemic blood pressure (BP). Abnormalities in arterioles are central to the development of major diseases such as hypertension, stroke, and microvascular complications of diabetes.
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