Publications by authors named "A C Gimenes"
Background: Because public health policies lay down guidelines for health promotion in specific populations, a review of policies devised for children and youth with special health care needs (CYSHCN) can reveal the actual degree of priority assigned to this population segment, while also highlighting relevant policies in this field.
Objective: To map the available evidence of public health policies for CYSHCN in member countries of the Organization for Economic Cooperation and Development (OECD) and Brazil.
Method: A scoping review protocol was developed as per the Joanna Briggs Institute (JBI) manual and the Preferred Reporting Items for Systematic Review and Meta-Analyses-Extension for Scoping Reviews (PRISMA-ScR) checklist, for application to the Web of Science (WoS), Scopus, PubMed, and Embase databases;to theLatin American and Caribbean Literature in Health Sciences (LILACS)multilingual thesaurus; and to gray literature.
Article Synopsis
- A persistent fungal colonizer can cause severe infections, especially in immunocompromised people, and is often resistant to standard antifungal treatments.
- Researchers evaluated the antifungal effectiveness of metabolites from a bacterial strain (F4a) and their combination with biologically synthesized silver nanoparticles (bioAgNP) against both free-floating and biofilm forms of the fungus.
- The study found that F4a and bioAgNP could significantly reduce fungal growth without harming mammalian cells, suggesting a promising new approach to treat fungal infections.
Mast cells (MCs) are main effector cells in allergic inflammation and after activation, they release stored (histamine, heparin, proteases) and newly synthesized (lipid mediators and cytokines) substances. In the gastrointestinal tract the largest MC population is located in the lamina propria and submucosa whereas several signals such as the cytokine IL-4, seem to increase the granule content and to stimulate a remarkable expansion of intestinal MCs. The broad range of MC-derived bioactive molecules may explain their involvement in many different allergic disorders of the gastrointestinal tract.
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- - Cisplatin (Cis) is an effective chemotherapy for cervical cancer, promoting DNA damage and apoptosis while influencing the expression of Annexin A1 (ANXA1) and inhibitor of DNA binding 1 (ID1) proteins in cervical cancer tissues and cells.
- - Observations from cervical tissue samples show a strong presence of ID1 in advanced Cervical Intraepithelial Neoplasia (CIN) stages, and in vitro experiments indicate that Cis treatments, alone or with ANXA1 peptide, boost ANXA1 expression while decreasing ID1 levels.
- - Treatment with ANXA1 peptide or Cis not only lowers cell growth and survival but also induces late-stage apoptosis and hinders the migration of cervical cancer
To evaluate the potential of three benzohydrazones (-), four acylhydrazones derived from isoniazid (INH-acylhydrazones) (-) and one hydrazone () as antituberculosis agents. Inhibitory and bactericidal activities were determined for the reference () strain and clinical isolates. Cytotoxicity, drug combinations and ethidium bromide accumulation assays were also performed.
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