Publications by authors named "A C Fay"
Importance: The open-label randomized phase 2 LACOG0415 trial evaluated 3 treatment strategies for patients with advanced castration-sensitive prostate cancer (CSPC): androgen deprivation therapy (ADT) plus abiraterone acetate and prednisone (AAP), apalutamide (APA) alone, or APA plus AAP.
Objective: To investigate the association of ADT plus AAP, APA alone, or APA plus AAP with health-related quality of life (HRQOL) in patients with advanced CSPC in the LACOG0415 trial.
Design, Setting, And Participants: The LACOG0415 randomized clinical trial comprised 128 patients with advanced CSPC who were randomized (1:1:1) to 1 of 3 treatment arms from October 16, 2017, to April 23, 2019.
Purpose: Lagophthalmos from facial nerve palsy is traditionally measured with patients in an upright position and may fail to identify positional variability. This study aims to assess the effects of body position, surgical technique, implant material, and patient demographics on lagophthalmos.
Methods: A multicenter prospective study was performed to evaluate positional changes in paralytic lagophthalmos and the effects of various patient and surgical factors.
Introduction: The normative relationship between lumbar intervertebral disc space height (DSH) and neuroforaminal dimensions (NFD) has yet to be defined.
Research Question: The purpose of this study was to investigate the relationship between lumbar DSH and NFD using computed tomography (CT), accounting for influences of patient demographic and anthropometric characteristics.
Materials And Methods: We analyzed CT imaging of 350 female and 350 male patients.
Orbital Intraosseous Abscess After Lateral Bony Orbital Decompression.
Ophthalmic Plast Reconstr Surg
December 2024
A 66-year-old woman status post bony lateral orbital decompression for thyroid eye disease presented with recurrent episodes of left lateral canthal edema and erythema, despite repeated courses of oral antibiotics, titanium hardware removal, and repeated exploratory orbitotomies with debridement and curettage. MRI later revealed an intraosseous fluid collection in the left greater sphenoid wing. Another exploratory orbitotomy was performed and an intraosseous abscess was identified.
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- Canavan disease (CD) is a rare genetic disorder caused by mutations in the ASPA gene, leading to high levels of N-acetylaspartate (NAA) in the body and severe developmental issues in infants.
- A subset of patients displays milder symptoms, possibly due to some remaining ASPA activity, raising the question of how urine NAA levels relate to this.
- A study found that individuals with the mild phenotype had significantly lower urine NAA levels and specific ASPA mutations that were absent in those with the typical phenotype, indicating that urine NAA can be used to differentiate between the two types of CD.