MicroRNA-199a-5p may be a diagnostic biomarker of primary ITP.

There is no diagnostic test for primary immune thrombocytopenia (ITP). Certain microRNAs have shown to have diagnostic potential in ITP. We validated 12 microRNAs identified from two previous studies to find a diagnostic biomarker.

Electrochemotherapy with bleomycin for bilateral ocular squamous cell carcinoma in a horse.

Objective: To describe the procedure and outcome of electrochemotherapy (ECT) with bleomycin as a first-line treatment for bilateral ocular surface squamous neoplasia (OSSN) in the eye of a horse.

Animal Studied: A client-owned 5-year-old Haflinger gelding with limbal-conjunctival squamous cell carcinoma.

Procedures: During general and local anesthesia, injection of bleomycin in the ocular tumor was followed by electroporation, applied with a 15 mm needle electrode, needles held parallel to the ocular surface.

Revisiting the speaker discriminatory power of vowel formant frequencies under a likelihood ratio-based paradigm: The case of mismatched speaking styles.

Differentiating subjects through the comparison of their recorded speech is a common endeavor in speaker characterization. When using an acoustic-based approach, this task typically involves scrutinizing specific acoustic parameters and assessing their discriminatory capacity. This experimental study aimed to evaluate the speaker discriminatory power of vowel formants-resonance peaks in the vocal tract-in two different speaking styles: Dialogue and Interview.

Technological lifelines: the everyday lived complexities of dependence and care of pediatric long-term tracheostomy.

Purpose: As the group of technology-dependent children with long-term tracheostomy continues to expand, we aimed to explore parents' lived experience of everyday life with a child dependent on long-term tracheostomy.

Materials And Methods: Six parents of four children were interviewed and the transcripts analyzed using Giorgi's descriptive phenomenology.

Results: All aspects of everyday life, parent-child interaction, and interaction with the surrounding outside world were affected by technology dependency.

A cost-effectiveness analysis of sentinel lymph node biopsy compared with lymphadenectomy in intermediate- and high-risk endometrial carcinoma.

Background: Sentinel lymph node biopsy (SLN) is increasingly used for surgical staging of endometrial carcinoma.

Objective: To estimate the effect and cost-effectiveness of the implementation of an SLN algorithm for surgical staging in patients with intermediate- and high-risk endometrial carcinoma compared with lymphadenectomy.

Methods: We performed a model-based, cost-effectiveness analysis using primary data from a tertiary referral hospital that included 829 patients with endometrial carcinoma undergoing surgical staging.