Publications by authors named "A C Engevik"
is a bacterial pathogen that has been implicated in severe gastrointestinal infections. has intrinsic green autofluorescence and the level of this autofluorescence is known to be increased by growth time and oxygen. Currently, it is unclear if dietary compounds or metabolites from the gut microbiota are able to enhance autofluorescence.
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- Intestinal tuft cells are specialized, rare cells that play a role in chemosensation and immune signaling, but their functions and structures are not fully understood.
- These cells have unique "tufts" made of actin-rich microvilli, which are thought to be organized by intermicrovillar adhesion complexes (IMACs) containing specific proteins like CDHR2 and CDHR5.
- Research findings indicate that CDHR2 and CDHR5 are critical for the structure of tuft cells in both mice and humans, with CDHR5 particularly concentrated on the apical surface of these cells.
Background & Aims: The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of intracellular substrates. P-glycoprotein is altered in disease, but the mechanisms that regulate the levels of P-glycoprotein are still being explored. The molecular motor myosin Vb (Myo5b) traffics diverse cargo to the apical membrane of intestinal epithelial cells.
View Article and Find Full Text PDFThe intestine is a complex organ composed of the small and the large intestines. The small intestine can be further divided into duodenum, jejunum, and ileum. Each anatomical region of the intestine has a unique function that is reflected by differences in cellular structure.
View Article and Find Full Text PDFBackground: Genetic discovery in very early-onset inflammatory bowel disease (VEO-IBD) can elucidate not only the origins of VEO-IBD, but also later-onset inflammatory bowel disease. We aimed to investigate the polygenic origins of VEO-IBD in a cohort with a high proportion of Hispanic patients.
Methods: Patients with VEO-IBD who underwent whole exome sequencing at our center were included.