Publications by authors named "A C Delmas"
Directed evolution generates novel biomolecules with desired functions by iteratively diversifying the genetic sequence of wildtype biomolecules, relaying the genetic information to the molecule with function, and selecting the variants that progresses towards the properties of interest. While traditional directed evolution consumes significant labor and time for each step, continuous evolution seeks to automate all steps so directed evolution can proceed with minimum human intervention and dramatically shortened time. A major application of continuous evolution is the generation of novel enzymes, which catalyze reactions under conditions that are not favorable to their wildtype counterparts, or on altered substrates.
View Article and Find Full Text PDFRecent debiasing studies have shown that a short, plain-English explanation of the correct solution strategy can improve reasoning performance. However, these studies have predominantly focused on English-speaking populations, who were tested with problem contents designed for an English-speaking test environment. Here we explore whether the key findings of previous debiasing studies can be extended to native French speakers living in continental Europe (France).
View Article and Find Full Text PDFReference-free Bayesian model for pointing errors of typein neurosurgical planning.
Int J Comput Assist Radiol Surg
July 2023
Article Synopsis
- The study addresses the challenge of identifying points of interest in neurosurgical imaging, where variability among experts often leads to errors in selecting these points.
- A new reference-free Bayesian model is proposed, which assesses the accuracy of point selections based on the consensus among multiple annotators, without needing prior ground truth data.
- The model successfully estimates the probability of selecting correct points at 82.6% to 88.6%, providing insights into the uncertainty of data accuracy and enabling clinical studies with fewer annotators.
Article Synopsis
- Many AML patients are ineligible for standard chemotherapy and often receive hypomethylating agents (HMAs) instead, but injectable forms can be burdensome due to hospital visits and side effects.
- A study involving interviews with 21 AML patients from Germany, the UK, and Spain aimed to understand patient preferences for treatment administration and the factors influencing their decisions.
- Results indicated that most patients preferred oral administration due to convenience, while efficacy and side effects were the top factors affecting their treatment choices.
Objective: The primary motor cortex (M1) is a usual target for therapeutic application of repetitive transcranial magnetic stimulation (rTMS), especially the region of hand motor representation. However, other M1 regions can be considered as potential rTMS targets, such as the region of lower limb or face representation. In this study, we assessed the localization of all these regions on magnetic resonance imaging (MRI) with the aim of defining three standardized M1 targets for the practice of neuronavigated rTMS.
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