Publications by authors named "A C Copeland"
Utilization of primary tumor samples for cancer neoantigen discovery.
J Immunother Cancer
January 2025
Background: The use of tumor-infiltrating T lymphocytes (TIL) that recognize cancer neoantigens has led to lasting remissions in metastatic melanoma and certain cases of metastatic epithelial cancer. For the treatment of the latter, selecting cells for therapy typically involves laborious screening of TIL for recognition of autologous tumor-specific mutations, detected through next-generation sequencing of freshly resected metastatic tumors. Our study explored the feasibility of using archived formalin-fixed, paraffin-embedded (FFPE) primary tumor samples for cancer neoantigen discovery, to potentially expedite this process and reduce the need for resections normally required for tumor sequencing.
View Article and Find Full Text PDFIntroduction: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is increasingly performed in young patients with peritoneal surface malignancies. Important quality of life (QoL) questions arise; however, there is limited research on fertility experiences in young women with carcinomatosis or following CRS/HIPEC.
Methods: Retrospective review of a prospective database evaluating women less than 45 ys who underwent CRS/HIPEC at the University of Pittsburgh Medical Center from January 1998 to 2020.
Background And Aims: Buying smaller-sized alcohol products can reduce alcohol consumption, but larger products have better value for money, which presents a barrier to switching. We tested whether proportional pricing prompts drinkers to buy smaller alcohol products and reduce alcohol purchasing.
Design, Setting And Participants: This study was an online experiment set in the United Kingdom, using hypothetical shopping tasks in which participants purchased different-sized products presented under proportional pricing (i.
Article Synopsis
- - From 2008 to 2020, the gender gap in match rates for general surgery residencies decreased, with female matriculants rising from 42% to 49%, showing progress toward gender parity in the field.
- - A similar trend was observed in surgical fellowships, where the percentage of females matched increased from 22% in 2007 to 37% in 2018, although males still significantly outnumber females.
- - The analysis of specific fellowship types (CGSO, pediatric surgery, colorectal surgery) indicated no significant differences in match rates between genders in the most recent cohort, suggesting a move towards equal opportunity.