Small molecules targeting the eubacterial β-sliding clamp discovered by combined and screening approaches.

Antibiotic resistance stands as the foremost post-pandemic threat to public health. The urgent need for new, effective antibacterial treatments is evident. Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets.

RNA-Based Next-Generation Sequencing in Non-Small Cell Lung Cancer patients: data from Campania, Italy.

Objective: ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations represent fundamental predictive biomarkers for advanced non-small cell lung cancer (NSCLC) patients to ensure the best treatment choice. In this scenario, RNA-based NGS approach has emerged as an extremely useful tool for detecting these alterations. In this study, we report our NGS molecular records on ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations detected by using a narrow RNA-based NGS panel, namely SiRe fusion.

Not all stains are made equal: impact of stain normalization on prostate cancer diagnosis.

Objective: Stain normalization is a technique used to standardize the color appearance of digital whole slide images (WSIs). This study aimed to assess the impact of digital stain normalization on prostate cancer diagnosis by pathologists.

Methods: A multi-institutional board of four pathologists evaluated 407 hematoxylin and eosin (H&E) prostate WSIs before and after stain normalization.

Addressing a Labor and Delivery Unit Practice Gap Through a Count Sheet Revision.

Unintentionally retained surgical items are never events that can be costly to patients and health care facilities. A labor and delivery unit quality improvement team at a southwestern Pennsylvania facility identified an opportunity for improvement associated with preventing retained surgical items. After reviewing the available literature, they identified a practice gap and decided to revise the count sheet.