Publications by authors named "A C Canal"
Long-term evaluation in BALBc mice of a triple mutant of Mycobacterium bovis and the Bacillus Calmette-Guérin as potential vaccines against bovine tuberculosis.
Vet Microbiol
January 2025
There is currently no commercial vaccine available against bovine tuberculosis (bTB). Mycobacterium bovis is the primary causative agent of bTB and is closely related to Mycobacterium tuberculosis, the pathogen responsible for human TB. Despite their limitations, mouse models are invaluable in early vaccine development due to their genetic diversity, cost-effectiveness, and the availability of research tools.
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- * In a trial, 74 heifers were vaccinated with different strains and then exposed to naturally infected animals, but the initial vaccination did not produce an adequate immune response, and re-vaccination did not show significant protection against the disease.
- * The study found a 23% transmission of wild-style strains in non-vaccinated animals, and while some vaccine candidates showed promise in reducing lesions, overall results indicated that further evaluation is needed, as current vaccines did not ensure improved outcomes.
Dysferlin-deficient limb girdle muscular dystrophy (LGMD R2), also referred to as dysferlinopathy, can be associated with respiratory muscle weakness as the disease progresses. Clinical practice guidelines recommend biennial lung function assessments in patients with dysferlinopathy to screen for respiratory impairment. However, lack of universal access to spirometry equipment and trained specialists makes regular monitoring challenging.
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- * The study focused on a tumor found in the penis of a bull from a dairy farm in Santa Fe, Argentina, employing staining and immunohistochemical analysis to characterize it.
- * Findings indicated the tumor was a neurofibrosarcoma, a type of nerve sheath tumor, marking the first recorded case of this tumor in a bull's penis.
Purpose: The main aim of this study was to investigate the clinical efficacy of speech therapy, delivered via tele-practice to patients with dysphonia. A secondary aim was to verify whether a telerehabilitation-only protocol could have a clinical efficacy similar to a combined telerehabilitation and in-person approach.
Methods: Thirty-two consecutive patients undergoing telerehabilitation for dysphonia were retrospectively considered.