Background: Efforts to mitigate the risk for perioperative cardiac events focus on both patient's and operation's risk and often include a preprocedural electrocardiogram (ECG). The merits of postprocedural ECG for detection of occult cardiac events occurring during surgery are unknown. We aim to explore the incidence of pre, and new postprocedural ECG pathologies in an intermediate-high risk population undergoing non-cardiac surgery.
View Article and Find Full Text PDFThe evolutionary conserved family of Selenoproteins performs redox-regulatory functions in bacteria, archaea and eukaryotes. Among them, members of the SELENOPROTEIN O (SELO) subfamily are located in mammalian and yeast mitochondria, but their functions are thus far enigmatic. Screening of T-DNA knockout mutants for resistance to the proline analogue thioproline (T4C), identified mutant alleles of the plant SELO homologue in Arabidopsis thaliana.
View Article and Find Full Text PDFBreadfruit is best known in connection with an infamously failed project: the 1789 mutiny against the Bounty, commanded by William Bligh. However, four years later, Bligh returned to the Pacific and fulfilled his commission, delivering breadfruit and other Pacific foods to Caribbean plantations. Placing these plant transfers in the emerg- ing sciences of food and nutrition in the eighteenth century, this essay examines the broader political project of what would much later be called 'the welfare state; which motivated British officials' interest in experimenting with novel ingredients and recipes to cheaply nourish a range of dependent populations in institutional settings.
View Article and Find Full Text PDFProline is not only an essential component of proteins but it also has important roles in adaptation to osmotic and dehydration stresses, redox control, and apoptosis. Here, we review pathways of proline biosynthesis in the three domains of life. Pathway reconstruction from genome data for hundreds of eubacterial and dozens of archaeal and eukaryotic organisms revealed evolutionary conservation and variations of this pathway across different taxa.
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