Publications by authors named "A C C Pignatari"
Article Synopsis
- * This study focuses on three multidrug-resistant (MDR) bacterial isolates found in the stool samples of swine and bovine in Brazil, all belonging to the same clone and carrying various antimicrobial resistance genes (ARGs).
- * Whole genome sequencing of one isolate revealed resistance to several types of antibiotics and highlighted genetic similarities with bacteria found in animals and humans in the USA and Malaysia, indicating a concerning spread of antibiotic-resistant pathogens in the food supply.
Article Synopsis
- The study investigates a New Delhi Metallo-β-lactamase (NDM)-1-producing Klebsiella quasipneumoniae subsp. quasipneumoniae (KQPN) strain found in Brazil, addressing a gap in whole genome sequencing data for Enterobacterales in the region.
- Whole genome sequencing was performed on the isolated strain (A-73.113) to analyze its antimicrobial susceptibility and genetic features, identifying resistance to several antibiotics and the presence of various virulence and plasmid-encoding genes.
- The findings contribute to the understanding of antimicrobial resistance and the genetic makeup of this clinically significant strain, emphasizing the need for ongoing surveillance.
Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022.
View Article and Find Full Text PDFAlthough it has been hypothesized that the acquisition of plasmids-especially those bearing virulence factors and antimicrobial resistance genes-increases the energetic burden and reduces the fitness of a bacterium in general, some results have challenged this view, showing little or no effect on fitness after plasmid acquisition, which may lead to change in the view that there are evolutionary barriers for a wide spread of such plasmids among bacteria. Here, to evaluate the fitness impact of plasmid-encoded antibiotic resistance and virulence genes, plasmids from O26:H11, O111:H8, and O118:H16 Shiga toxin-producing Escherichia coli (STEC) human and bovine isolates were transferred to the non-virulent E. coli HS and K-12 MG1655 strains.
View Article and Find Full Text PDFCarbapenem-resistant Klebsiella pneumoniae bloodstream infections in haematological malignances and hematopoietic stem cell transplantation: Clinical impact of combination therapy in a 10-year Brazilian cohort.
PLoS One
January 2024
Article Synopsis
- Bacterial bloodstream infections (BSI) caused by carbapenem-resistant Klebsiella pneumoniae (CRKp) are prevalent in patients with hematological malignancies and stem cell transplant recipients.
- A study of 65 BSI episodes over 10 years identified acute leukemias as the most common underlying condition and highlighted mucosal barrier injury in the gastrointestinal tract as the primary cause of infection.
- The research found that timely and appropriate antibiotic treatment significantly improved survival rates, while factors like hypotension at presentation and concurrent invasive fungal diseases were linked to higher 30-day mortality.