Microglia and Immune cells interactions in multiple sclerosis cognitive impairment: a postmortem study.

Multiple Sclerosis (MS), a neuroinflammatory disease of the central nervous system, is one of the commonest causes of non-traumatic disability among young adults. Impaired cognition arises as an impactful symptom affecting more than 50% of the patients and with substantial impact on social, economic, and individual wellbeing. Despite the lack of therapeutic strategies, many efforts have been made to understand the mechanisms behind cognitive impairment in MS patients.

Prioritising Relevant Polychlorinated Naphthalene (PCN) Congeners for Human Dietary Exposure Studies.

Following a decline in the production and use of polychlorinated naphthalenes (PCNs) and the restrictions introduced by the Stockholm Convention, dietary intake represents the most significant pathway of human exposure to these dioxin-like contaminants. PCNs occur ubiquitously in foods, originating from the legacy of historical production that is now globally redistributed, as well as from ongoing industrial and domestic combustion sources which have a stronger influence on occurrence patterns in countries where they were not produced. Recent studies have benefited from a wider set of available PCN reference standards, enabling more accurate reporting of a diverse range of congeners.

Staphylococcus caprae Infections in Neonatal Intensive Care Units: A Report of Two Cases.

() is a coagulase-negative staphylococci. This group of bacteria is typically part of the skin flora but can become pathogenic in susceptible hosts, such as preterm infants with prolonged stays in neonatal intensive care units. Two preterm newborns with late-onset sepsis caused by , one of whom also developed meningitis.

Applicability of the Scottish screen-detected polyp cancer study (SSPoCS) algorithm in a multicentric cohort in the management of malignant colorectal polyps.

Background/objectives: Robust evidence regarding the management after endoscopic resection of malignant colorectal polyps (MCP) is lacking. Inconsistencies in reporting on potential prognostic factors hinder the decision process. To address these issues, the Scottish Screen-detected Polyp Cancer Study (SSPoCS) introduced an algorithm based in two easily obtainable variables: resection margin and lymphovascular invasion.