Biomarkers.

Background: Cerebrovascular changes are often reported in normal aging, Alzheimer's disease (AD), and vascular dementia (VaD). Cerebral perfusion and cerebrovascular reactivity (CVR) both decrease with dementia compared to healthy aging; as these changes occur prior to symptomatic onset and in distinct brain regions, perfusion and CVR may act as complementary biomarkers of early cerebrovascular changes. These biomarkers can be measured using MRI methods, yielding macrovascular measures of perfusion and CVR.

Alzheimer's Imaging Consortium.

Background: Cerebrovascular changes are often reported in normal aging, Alzheimer's disease (AD), and vascular dementia (VaD). Cerebral perfusion and cerebrovascular reactivity (CVR) both decrease with dementia compared to healthy aging; as these changes occur prior to symptomatic onset and in distinct brain regions, perfusion and CVR may act as complementary biomarkers of early cerebrovascular changes. These biomarkers can be measured using MRI methods, yielding macrovascular measures of perfusion and CVR.

Transplantation of a genetically modified porcine heart into a live human.

Following our previous experience with cardiac xenotransplantation of a genetically modified porcine heart into a live human, we sought to achieve improved results by selecting a healthier recipient and through more sensitive donor screening for potential zoonotic pathogens. Here we transplanted a 10-gene-edited pig heart into a 58-year-old man with progressive, debilitating inotrope-dependent heart failure due to ischemic cardiomyopathy who was not a candidate for standard advanced heart failure therapies. He was maintained on a costimulation (anti-CD40L, Tegoprubart) blockade-based immunomodulatory regimen.

Genetically engineered pig heart transplantation in non-human primates.

Background: Improvement in gene modifications of donor pigs has led to the prevention of early cardiac xenograft rejection and significantly prolonged cardiac xenograft survival in both heterotopic and orthotopic preclinical non-human primate (NHP) models. This progress formed the basis for FDA approval for compassionate use transplants in two patients.

Methods: Based on our earlier report of 9-month survival of seven gene-edited (7-GE) hearts transplanted (life-supporting orthotopic) in baboons, we transplanted 10 gene-edited pig hearts into baboons (n = 4) using non-ischemic continuous perfusion preservation (NICP) and immunosuppression regimen based on co-stimulation blockade by anti-CD40 monoclonal antibody.

Prevalence, patterns, and predictors of prescribing medications for opioid use disorder (MOUD) in the Inpatient setting.

Background: There are many barriers to prescribing medications for opioid use disorder (MOUD). This study evaluates the prevalence, patterns, and predictors of inpatient MOUD prescribing at discharge to patients with a diagnosis of opioid use/opioid use disorder (OUD) that developed opioid withdrawal during their hospital stay.

Methods: This multicenter, retrospective cross-sectional study occurred at three hospitals in Arizona.