Publications by authors named "A C Bergh"
Sport-related injuries have been reported to occur in around one-third of agility dogs. Higher bar height in competitions has been shown to increase odds of an injury. This study evaluated the effect of bar height on the kinetics and kinematics at take-off to a bar jump.
View Article and Find Full Text PDFHuman dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis and experimental profiling. Our goal is a model that provides a preliminary estimate of the dose for a given exposure target based on chemical structure.
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- Changes in deoxyribonucleoside triphosphate (dNTP) pools are tied to higher mutation rates and genome instability in unicellular organisms, but their role in mammalian tumor development is not well understood.
- A mouse model with a specific mutation in ribonucleotide reductase (RRM1-Y285A) showed decreased enzyme activity, leading to reduced dATP and dGTP levels, resulting in shorter lifespans and earlier tumor onset.
- Analysis of the tumors indicated unique mutational signatures similar to those found in human cancers with related mutations in ribonucleotide reductase, suggesting that dNTP metabolism mutations may drive cancer development.
Background: Data on the efficacy and safety of screening for prostate cancer with magnetic resonance imaging (MRI) are needed from studies of follow-up screening.
Methods: In a population-based trial that started in 2015, we invited men who were 50 to 60 years of age to undergo prostate-specific antigen (PSA) screening. Men with a PSA level of 3 ng per milliliter or higher underwent MRI of the prostate.
TGFβ potently modifies the extracellular matrix (ECM), which is thought to favor tumor cell invasion. However, the mechanism whereby the cancer cells employ the ECM proteins to facilitate their motility is largely unknown. In this study we used RNA-seq and proteomic analysis to examine the proteins secreted by castration-resistant prostate cancer (CRPC) cells upon TGFβ treatment and found that thrombospondin 1 (THBS1) was observed to be one of the predominant proteins.
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