Publications by authors named "A C A Roque"
Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models.
PLoS Comput Biol
December 2024
Astrocytes respond to neurotransmitters by increasing their intracellular Ca2+ concentration (Ca2+ signals). While glutamate released by neurons trigger Ca2+ signals through IP3- and glutamate transporter-dependent mechanisms, dopamine released in distant sites activates astrocytes via dopaminergic receptors. However, little is known about the modulatory effects of dopamine on glutamate-evoked astrocytic activity.
View Article and Find Full Text PDFPurpose: Myopia, a leading cause of correctable visual impairment, is projected to affect nearly 50% of the global population by 2050, posing a significant public health challenge. Understanding its prevalence and associated factors, particularly in children, is crucial for devising prevention and intervention strategies. This study aims to determine the proportion of myopia in school-aged children in Portugal and to examine the correlation between myopia occurrence and various environmental and genetic factors.
View Article and Find Full Text PDFArticle Synopsis
- - Vitamin D insufficiency and deficiency are common in chronic kidney disease (CKD) patients, prompting a study to create a pharmacokinetic model for oral cholecalciferol (VitD) and its metabolites in this population.
- - The study involved 29 CKD patients who were given a single dose of oral VitD, using nonlinear mixed effects modeling to analyze how the drug and its metabolites are processed in the body.
- - The results indicate that personalized dosing strategies of 600 to 1000 I.U. of VitD per day may be ideal for reaching target 25-hydroxyvitamin D levels, potentially improving treatment for CKD patients.