Prospects of prostanoid therapy. Preliminary results.

Background: To evaluate the efficacy of treatment with prostaglandins (Iloprost and Alprostadil) in patients with peripheral arterial disease in whom a surgical act or a redo operation is not proposable and to set the role of these drugs in the therapy of arterial diseases.

Methods: We analyzed the results of 96 treatments in patients with peripheral arterial diseases of different etiology, treated in the Day Hospital in the Division of Vascular Surgery from the 1/1/1993 to the 30/6/1998. The efficacy of the treatment has been evaluated on the basis of the clinical picture (healing or reduction of ulcers, reduction of rest-pain, improvement of the ability to walk).

[Considerations on 12 cases of mesenteric embolism treated surgically].

Twelve cases of mesenteric artery embolism surgically treated with a surviving rate of 66% are reported. The Authors point out the diagnostic features and the various factors affecting the surgical result.

[Follow-up in femoral artery embolectomy].

The results of 112 femoral embolectomies performed on 100 patients were reviewed. Operative mortality rate was 15% and early amputation (within 30 day-after the procedure) 18%. The role of early amputation was closely related to the time of leg ischemia.