Early health technology assessment of gene silencing therapies for lowering lipoprotein(a) in the secondary prevention of coronary heart disease.

Background: Olpasiran and pelacarsen are gene-silencing therapies that lower lipoprotein(a). Cardiovascular outcome trials are ongoing. Mendelian randomisation studies estimated clinical benefits from lipoprotein(a) lowering.

Comparing self-reported and measured hypertension and hypercholesterolaemia at standard and more stringent diagnostic thresholds: the cross-sectional 2010-2015 Busselton Healthy Ageing study.

Background: Population health behaviour and risk factor surveys most often rely on self-report but there is a lack of studies assessing the validity of self-report using Australian data. This study investigates the sensitivity, specificity and agreement of self-reported hypertension and hypercholesterolaemia with objective measures at standard and more stringent diagnostic thresholds; and factors associated with sensitivity and specificity of self-report at different thresholds.

Methods: This study was a secondary analysis of a representative community-based cross-sectional sample of 5,092 adults, aged 45-69 years, residing in Busselton, Western Australia, surveyed in 2010-2015.

Laparoscopic sleeve gastrectomy in a patient with and Kartagener syndrome: an unusual surgical conundrum.

Kartagener syndrome is a rare autosomal recessive condition. Approximately 25% of those with suffer the syndrome. With the rising overall number and indications for bariatric surgery, this condition will be increasingly recognised.

Same day surgery: results of a patient satisfaction survey.

Same day surgery patients have unique needs, distinct from those of traditional long-stay inpatients and outpatients. Their postoperative needs at home are central to achieving complete recovery and ensuring there are no unplanned readmissions to hospital. In a quality improvement project at Royal Perth Hospital, a patient satisfaction questionnaire survey has attempted to measure the clinical outcome of same day surgery patients and whether this is influenced by factors such as the specific information expectations and needs of these patients, including their postoperative information needs and expectations.