Retinoid modulation of insulin-like growth factor-binding proteins and inhibition of breast carcinoma proliferation.

Retinoids induce cellular differentiation and inhibit cellular proliferation. Proliferation of human breast carcinoma cells in vitro is markedly inhibited by these compounds. On the other hand, insulin-like growth factors (IGFs) and their receptors seem to be involved in the growth of certain breast carcinoma cells by autocrine or paracrine effects.

Secretion and binding of transforming growth factor beta by scleroderma and normal dermal fibroblasts.

The production and binding of transforming growth factor beta (TGF beta) were compared in dermal fibroblast lines derived from scleroderma patients and normal control donors. The mean +/- SEM 24-hour level of secretion of TGF beta by fibroblast lines derived from the involved skin of scleroderma patients was 30.8 +/- 5.