Performance Analysis of Emergency Room Episodes Through Process Mining.

The performance analysis of Emergency Room episodes is aimed at providing decision makers with knowledge that allows them to decrease waiting times, reduce patient congestion, and improve the quality of care provided. In this case study, Process Mining is used to determine which activities, sub-processes, interactions, and characteristics of episodes explain why some episodes have a longer duration. The employed method and the results obtained are described in detail to serve as a guide for future performance analysis in this domain.

Detection and quantification of flow consistency in business process models.

Business process models abstract complex business processes by representing them as graphical models. Their layout, as determined by the modeler, may have an effect when these models are used. However, this effect is currently not fully understood.

Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects.

Objective: Spontaneous parathyroid hormone (PTH) secretory dynamics include tonic and pulsatile components. It is not known how glucocorticoids might alter these secretory dynamics.

Design: The aim of our study was to evaluate spontaneous fluctuations in serum PTH levels in six adult male patients (aged 31-64 years) receiving chronic (>6 months) therapy with glucocorticoids (daily dosage >7.

Leptin stimulates growth hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study.

The aim of this study was to examine the effect of recombinant human leptin on growth hormone (GH) secretion in perifused anterior pituitary slices from adult pigs. Anterior pituitary slices from sows were perifused and treated with recombinant human leptin (10 nM) and GH-releasing hormone (GHRH; 1 nM). In some experiments, pituitary slices were coincubated with stalk median eminence (SME).