Publications by authors named "A Bunschoten"
Article Synopsis
- Current whole sporozoite (SPZ) vaccines show limited effectiveness in malaria-endemic regions, possibly due to reduced immune responses from prior malaria exposure.
- Researchers have developed a method to enhance SPZ vaccine immunogenicity by attaching a TLR7 agonist-based adjuvant, leading to significantly higher immune responses, including a 35-fold increase in pro-inflammatory IL-6 production.
- Mice immunized with this enhanced SPZ vaccine demonstrated improved production of specific immune cells, suggesting that this chemical augmentation strategy could make malaria vaccines more effective.
Background: Surgically induced nerve damage is a common but debilitating side effect. By developing tracers that specifically target the most abundant protein in peripheral myelin, namely myelin protein zero (P0), we intend to support fluorescence-guided nerve-sparing surgery. To that end, we aimed to develop a dimeric tracer that shows a superior affinity for P0.
View Article and Find Full Text PDFMany pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host-guest chemistry, we complexed onto the surface of a poorly immunogenic bacterium (Staphylococcus aureus) a TLR7 agonist-based adjuvant.
View Article and Find Full Text PDFHierarchically built-up multicompartment nanoaggregate systems are of interest for, , novel materials and medicine. Here we present a versatile strategy to generate and unambiguously characterize complex coacervate-core micelles by exploiting four different dendrimeric subcomponents as core-units. The resulting mesoscale structures have a hydrodynamic diameter of 50 nm and a core size of 33 nm, and host about thirty 6th generation polyamidoamine (PAMAM) dendrimers.
View Article and Find Full Text PDFBackground: Due to the interaction between skeletal muscle ageing and lifestyle factors, it is often challenging to attribute the decline in muscle mass and quality to either changes in lifestyle or to advancing age itself. Because many of the physiological factors affecting muscle mass and quality are modulated by physical activity and physical activity declines with age, the aim of this study is to better understand the effects of early ageing on muscle function by comparing a population of healthy older and young males with similar physical activity patterns.
Methods: Eighteen older (69 ± 2.