Publications by authors named "A Buil"
Article Synopsis
- Large biobank samples allow researchers to combine detailed family histories and genetic data to investigate complex diseases.
- The study introduces a new method called Pearson-Aitken Family Genetic Risk Scores (PA-FGRS) to estimate disease risk based on family medical histories.
- Applying PA-FGRS to major depressive disorder (MDD) shows improved understanding of genetic factors and clinical variability, and enhances the effectiveness of genetic studies across different complex conditions.
Article Synopsis
- - MDD and CVD commonly occur together, leading to higher health risks, and they share many genetic risk factors, with notable genetic overlaps found in specific brain regions like the thalamus.
- - The research identified seven genetic loci linked to both disorders and highlighted that factors like inflammation and lifestyle contribute to the shared risk between MDD and atherosclerotic CVD.
- - The findings suggest that genetic predisposition to MDD increases the risk of CVD, while the reverse is less evident, indicating a specific immunometabolic subtype of MDD that may be targeted for better prevention of CVD.
[Skin-to-skin relaxation: psychomotor mediation in the neonatal unit].
Soins Pediatr Pueric
August 2024
Skin-to-skin relaxation is offered by one of the department's psychomotor therapists, within a precise framework of clearly defined indications and contraindications. The aim of this intervention modality is to support the parent-baby relationship in a context of vulnerability. A self-questionnaire for parents was used to take stock of the practice of skin-to-skin relaxation at the Centre Hospitalier Intercommunal de Créteil.
View Article and Find Full Text PDFImportance: Recurrent copy number variants (rCNVs) have been associated with increased risk of psychiatric disorders in case-control studies, but their population-level impact is unknown.
Objective: To provide unbiased population-based estimates of prevalence and risk associated with psychiatric disorders for rCNVs and to compare risks across outcomes, rCNV dosage type (deletions or duplications), and locus features.
Design, Setting, And Participants: This genetic association study is an analysis of data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) case-cohort sample of individuals born in Denmark in 1981-2008 and followed up until 2015, including (1) all individuals (n = 92 531) with a hospital discharge diagnosis of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder, major depressive disorder (MDD), or schizophrenia spectrum disorder (SSD) and (2) a subcohort (n = 50 625) randomly drawn from the source population.
Article Synopsis
- Major depressive disorder (MDD) and cardiovascular disease (CVD) often occur together, leading to increased health issues and mortality rates.
- A study discovered that many genetic risk factors for CVD overlap with those for MDD, indicating a shared biological basis, particularly involving specific brain regions and cell types.
- The findings suggest that genetic predisposition to MDD can increase the risk of developing CVD, while lifestyle and metabolic factors also play significant roles, potentially creating an immunometabolic subtype of MDD more closely linked with CVD.