On the use of elliptic PDEs for the parameterisation of planar multipatch domains: Part 1: Numerical algorithms and foundations of parametric control.

This paper presents a parameterisation framework based on (inverted) elliptic PDEs for addressing the planar parameterisation problem of finding a valid description of the domain's interior given no more than a spline-based description of its boundary contours. The framework is geared towards isogeometric analysis (IGA) applications wherein the physical domain is comprised of more than four sides, hence requiring more than one patch. We adopt the concept of harmonic maps and propose several PDE-based problem formulations capable of finding a valid map between a convex parametric multipatch domain and the piecewise-smooth physical domain with an equal number of sides.

An interior penalty coupling strategy for isogeometric non-conformal Kirchhoff-Love shell patches.

This work focuses on the coupling of trimmed shell patches using Isogeometric Analysis, based on higher continuity splines that seamlessly meet the requirement of Kirchhoff-Love-based discretizations. Weak enforcement of coupling conditions is achieved through the symmetric interior penalty method, where the fluxes are computed using their correct variationally consistent expression that was only recently proposed and is unprecedentedly adopted herein in the context of coupling conditions. The constitutive relationship accounts for generically laminated materials, although the proposed tests are conducted under the assumption of uniform thickness and lamination sequence.

A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome.

Invariant natural killer T (iNKT) cells, a unique T cell population, lend themselves for use as adoptive therapy due to diverse roles in orchestrating immune responses. Originally developed for use in cancer, agenT-797 is a donor-unrestricted allogeneic ex vivo expanded iNKT cell therapy. We conducted an open-label study in virally induced acute respiratory distress syndrome (ARDS) caused by the severe acute respiratory syndrome-2 virus (trial registration NCT04582201).

Belief Inflexibility and Cognitive Biases in Anorexia Nervosa-The Role of the Bias against Disconfirmatory Evidence and Its Clinical and Neuropsychological Correlates.

The aim of this study was to explore, in a sample of patients with a diagnosis of AN, the ability to question their first impression and, in particular, the willingness to integrate their prior ideas and thoughts with additional progressive incoming information. A total of 45 healthy women and 103 patients with a diagnosis of AN, consecutively admitted to the Eating Disorder Padova Hospital-University Unit, underwent a broad clinical and neuropsychological assessment. All participants were administered the Bias Against Disconfirmatory Evidence (BADE) task, which specifically investigates belief integration cognitive bias.