Publications by authors named "A Budzianowski"
Article Synopsis
- New complexes of 2-(N,N-dimethylamino)pyridine (2-DMAP) and 4-(N,N-dimethylamino)pyridine (4-DMAP) were synthesized with chloranilic acid (CLA) and characterized using various methods including X-ray diffraction and NMR spectroscopy.
- Both complexes demonstrated proton transfer, leading to strong hydrogen bonds, and were found to have different crystallization structures.
- Thermal analysis indicated that the methyl groups in 4-DMAP + CLA exhibit faster motion at room temperature compared to the slower motion of CH groups in 2-DMAP + CLA due to steric effects.
The structure and stoichiometry of a new metal-free and ammonium-free compound [dabcoH]HOBr (where [dabcoH] = 1,4-di-aza-bicyclo-[2.2.2]octane dication) correspond to the general formula characteristic of perovskites.
View Article and Find Full Text PDFRacemic ketoprofen (KP) and β-cyclodextrin (β-CD) powder samples from co-precipitation (), evaporation (), and heating-under-reflux () were analysed using X-ray techniques and nuclear magnetic resonance (NMR) spectroscopy. On the basis of NMR studies carried out in an aqueous solution, it was found that in the samples obtained by methods and there were large excesses of β-CD in relation to KP, 10 and 75 times, respectively, while the sample obtained by method contained equimolar amounts of β-CD and KP. NMR results indicated that KP/β-CD inclusion complexes were formed and the estimated binding constants were approximately 2400 M, showing that KP is quite strongly associated with β-CD.
View Article and Find Full Text PDFCholinesterase inhibitors are potent therapeutics in the treatment of Alzheimer's disease. Among them, dual binding ligands have recently gained a lot of attention. We discovered novel dual-binding cholinesterase inhibitors, using "clickable" fragments, which bind to either catalytic active site (CAS) or peripheral anionic site (PAS) of the enzyme.
View Article and Find Full Text PDFAtropisomers are very interesting stereoisomers having axial chirality resulting from restricted rotation around single bonds and are found in various classes of compounds. Substituted arylpyridines are an important group of them. A regio- and atropselective Suzuki-Miyaura cross-coupling reaction on 3,4,5-tribromo-2,6-dimethylpyridine was studied.
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