Publications by authors named "A Buchan"
Inflammation is largely detrimental early in the acute phase of stroke but beneficial at more chronic stages. Fasting has been shown to reduce inflammation acutely. This preliminary study aimed to determine whether post-ischemic fasting improves stroke outcomes through attenuated inflammation.
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- The study investigates the role of brain pericytes in the microvascular no-reflow phenomenon after reopening an artery during ischemic stroke.
- It finds that mTOR inhibition via rapamycin reduces pericyte contraction during simulated ischemia, though it doesn't significantly affect cell survival.
- In a mouse model, rapamycin improves capillary diameter and increases the number of open capillaries following arterial recanalization, suggesting it could be a helpful treatment to enhance blood flow in the brain after a stroke.
Background: Comprehensive stroke centres across England have developed investment proposals, showing the estimated increases in mechanical thrombectomy (MT) treatment volume that would justify extending the standard hours to a 24/7 service provision. These investment proposals have been developed taking a financial accounting perspective, that is by considering the financial revenues from tariff income. However, given the pressure put on local health authorities to provide value for money services, an affordability question emerges.
View Article and Find Full Text PDFIntroduction: More than 3 years into the pandemic, there is persisting uncertainty as to the etiology, biomarkers, and risk factors of Post COVID-19 Condition (PCC). Serological research data remain a largely untapped resource. Few studies have investigated the potential relationships between post-acute serology and PCC, while accounting for clinical covariates.
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