Publications by authors named "A Bucalossi"

Article Synopsis
  • * The study focused on analyzing memory B cells and antibody responses in allo-HCT recipients after receiving multiple doses of the mRNA-1273 vaccine, noting a significant increase in spike-specific B cells post-vaccination.
  • * Results showed that these patients require more booster doses to achieve a similar immune response to healthy individuals, with a majority developing immunity against both the original virus and the BA.1 variant.
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Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections.

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Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of hematopoietic stem cell transplantation (HSCT) associated with kidney injury and significant mortality. Recent studies indicate that dysregulation of the alternate complement pathway may be at the basis of the development of TA-TMA. Currently, there are no pre-transplant screening tools to identify patients at risk.

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