Publications by authors named "A Brett"
Article Synopsis
- Quantitative biomechanical gait analysis is crucial for diagnosing and treating injuries and diseases, but there is a need for standardized benchmark datasets as these labs often function in isolation.
- To fill this gap, an open biomechanics dataset has been created, featuring data from 1798 healthy and injured participants of various ages walking and running on a treadmill.
- The dataset, available on Figshare+, includes raw data, metadata, and tutorials on analyzing the data, covering topics from basic file loading to advanced statistical methods like principal component analysis and clustering.
Objectives: To evaluate the efficacy and safety of intra-articular injections of a novel aggrecan mimetic, SB-061, in subjects with knee osteoarthritis (OA).
Methods: This was a randomized, placebo-controlled, double-blind phase II study comparing intra-articular injections of SB-061 with placebo (isotonic saline) for 52 weeks, administered at baseline, Wk 16, and Wk 32. Eligible subjects had a KL grade of 2 or 3 on X-ray of the target knee and a Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) pain score ≥20 out of 50 at screening and baseline visits.
Background: Osteophytes are commonly used to diagnose and guide knee osteoarthritis (OA) treatment, but their causes are unclear. Although they are not typically the focus of knee arthroplasty surgeons, they can predict case difficulty and length. Furthermore, their extent and location may yield much information about the knee joint status.
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- The study aimed to determine if direct transport to a cardiac arrest center after an out-of-hospital cardiac arrest (OHCA) improved survival rates in New Zealand.
- It analyzed data from 2,297 OHCA patients over five years, using propensity score matching, but found no significant difference in 30-day survival rates between those transported to cardiac arrest centers (56%) and non-cardiac centers (45%).
- Factors like having a shockable rhythm and receiving bystander CPR increased survival odds, while older age and being of Māori or Pacific Peoples ethnicity were linked to lower survival. Further research is needed for more definitive results.
Objective: Developing new therapies for knee osteoarthritis (KOA) requires improved prediction of disease progression. This study evaluated the prognostic value of clinical clusters and machine-learning derived quantitative 3D bone shape B-score for predicting total and partial knee replacement (KR).
Design: This retrospective study used longitudinal data from the Osteoarthritis Initiative.