Publications by authors named "A Breslavsky"
COVID-19 vaccination and acute infection result in cellular and humoral immune responses with various degrees of protection. While most studies have addressed the difference in humoral response between vaccination and acute infection, studies on the cellular response are scarce. We aimed to evaluate differences in immune response among vaccinated patients versus those who had recovered from COVID-19.
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- Since late 2021, the Omicron variant (B.1.1.529) of SARS-CoV-2 has become the dominant strain globally, replacing Delta (B.1.617.2), which had worse outcomes despite similar transmission rates.
- A study of patients on maintenance hemodialysis showed that those infected with Delta had significantly more severe COVID-19 cases and higher mortality rates (19.2%) compared to those infected with Omicron (0%).
- Even though Omicron infections were generally milder, there was still a notable 90-day mortality rate among affected patients, highlighting the ongoing risks associated with COVID-19 for those with pre-existing conditions.
Article Synopsis
- - The study explores the concept of remission for severe asthma patients on biological treatments, aiming to establish clearer criteria for successful remission which typically includes reduced steroid use, fewer exacerbations, minimal symptoms, and improved lung function.
- - In a cross-sectional analysis of 39 adults with severe asthma, the research found that a significant percentage met some remission criteria, but there was considerable variability in outcomes depending on the specific criteria used.
- - The findings suggest that while achieving clinical remission is possible for patients using biological therapies, there is a need for more consistent and clearly defined criteria to effectively measure and compare remission across different patients.
Article Synopsis
- The study examines how the humoral response (antibody production) after the first two doses of the BNT162b2 COVID-19 vaccine can predict responses to subsequent booster shots.
- Researchers followed hospital health care workers who received three vaccine doses and conducted serological tests to measure antibody levels at different intervals.
- Findings indicate that lower antibody levels and rapid declines in antibody levels after the second dose are strong indicators of a similarly low response to booster vaccinations.