Publications by authors named "A Bredin"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease, with around 20% of cases linked to family history, but genetic testing is often limited to those with a family background or younger onset.
- A study analyzed patients with sporadic ALS in the UK to assess the likelihood of getting clinically actionable genetic test results based on age, finding probabilities decreasing from younger to older age groups.
- The research indicated that restricting testing to those under 40 years led to missing nearly all clinically valuable genetic results, suggesting that both age of onset and family history should not restrict genetic testing in ALS patients.
Impact of the covid-19 pandemic on amyotrophic lateral sclerosis care in the UK.
Amyotroph Lateral Scler Frontotemporal Degener
February 2023
The Covid-19 pandemic has impacted healthcare. Our aim was to identify how amyotrophic lateral sclerosis (ALS) care in the UK has been affected by the pandemic by exploring the experiences of people living with ALS (plwALS), healthcare professionals (HCPs) working with plwALS, and ALS care centers. Three surveys were carried out to explore the experiences of plwALS, HCPs and ALS care centers during the pandemic.
View Article and Find Full Text PDFMotor Neuron Disease Register for England, Wales and Northern Ireland-an analysis of incidence in England.
Amyotroph Lateral Scler Frontotemporal Degener
February 2021
Amyotrophic lateral sclerosis (ALS) has a reported incidence of 1-2/100,000 person-years. It is estimated that there are 5000 people with ALS in the UK at any one time; however, the true figure and geographical distribution, are unknown. In this study, we describe the establishment of a population register for England, Wales, and Northern Ireland and report-estimated incidence.
View Article and Find Full Text PDFRasch analysis of the Forgotten Joint Score in patients undergoing knee arthroplasty.
Knee Surg Sports Traumatol Arthrosc
June 2019
Purpose: The purpose of this study was to test the hypothesis that the "Forgotten Joint Score" (FJS-12) is a unidimensional interval-level scale. Unidimensionality refers to measuring a single attribute, i.e.
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