Publications by authors named "A Braundmeier-Fleming"
Article Synopsis
- Endometriosis is linked to changes in gut and urinary microbiomes, which can be influenced by the number of sexual partners and the type of treatments patients receive.
- Researchers collected and analyzed samples from patients with endometriosis and control individuals to understand the effects of hormonal therapy and surgical interventions on microbial profiles.
- Results showed that higher sexual partner exposure can worsen microbial imbalances in endometriosis patients, potentially reducing the effectiveness of treatments like hormone therapy and surgery.*
Article Synopsis
- Epithelial ovarian cancer (OC) is a highly lethal cancer affecting women, with significant mortality rates and challenges in treatment due to resistance to platinum-based chemotherapy.
- The study explored the relationship between peripheral immune profiles, peritoneal microbial features, and the chemotherapy response in patients with OC, finding that inflammation levels at surgery were linked to longer disease-free intervals.
- Results indicated that unique microbial features in the peritoneal fluid could help in predicting responses to chemotherapy, though self-rated health scores did not prove to be reliable indicators of immune status in these participants.
Endometrial cancer (EC) is the most prevalent gynecological malignancy. Abnormal accumulation of sterol-O-acyl transferase 1 (SOAT1) and SOAT1-mediated cholesterol ester (CE) contributes to cancer progression in various malignancies, including ovarian cancer. Therefore, it was hypothesized that similar molecular changes may occur in EC.
View Article and Find Full Text PDFEndometriosis is defined as the growth of endometrial tissue in ectopic locations, and is associated with altered immune and microbial phenotypes. It is unclear if these changes are the result of the disease or may be causative. We induced endometriosis in non-human primates (Papio Anubis) to test our hypothesis that the growth of endometriotic lesions results in alterations in immune and microbial dynamics that may advance disease progression.
View Article and Find Full Text PDFEndometriosis is an estrogen dependent gynecological disease associated with altered microbial phenotypes. The association among endogenous estrogen, estrogen metabolites, and microbial dynamics on disease pathogenesis has not been fully investigated. Here, we identified estrogen metabolites as well as microbial phenotypes in non-diseased patients (n = 9) and those with pathologically confirmed endometriosis (P-EOSIS, n = 20), on day of surgery (DOS) and ~1-3 weeks post-surgical intervention (PSI).
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