Osimertinib in a patient with end-stage kidney disease not on hemodialysis.

Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) effective in non- small cell lung cancer (NSCLC) with EGFR mutations. Since the drug is primally eliminated by the fecal route no dose adjustment is needed in patient with chronic-kidney disease (CKD); despite this there is limited data about its safety in cancer patients with end-stage renal disease (ESRD). Herein, we reported a case report of a 77-year-old woman, diagnosed in 2018 with lung adenocarcinoma EGFR mutated with lymph nodal and cerebral metastasis, who started Osimertinib 80 mg/day.

Highly Photostable Zn-Treated Halide Perovskite Nanocrystals for Efficient Single Photon Generation.

Achieving pure single-photon emission is essential for a range of quantum technologies, from quantum computing to quantum key distribution to quantum metrology. Among solid-state quantum emitters, colloidal lead halide perovskite (LHP) nanocrystals (NCs) have attracted considerable interest due to their structural and optical properties, which make them attractive candidates for single-photon sources (SPSs). However, their practical utilization has been hampered by environment-induced instabilities.

Quantum Vacuum Excitation of a Quasinormal Mode in an Analog Model of Black Hole Spacetime.

Vacuum quantum fluctuations near horizons are known to yield correlated emission by the Hawking effect. We use a driven-dissipative quantum fluid of microcavity polaritons as an analog model of a quantum field theory on a black-hole spacetime and numerically calculate correlated emission. We show that, in addition to the Hawking effect at the sonic horizon, quantum fluctuations may result in a sizable stationary excitation of a quasinormal mode of the field theory.

High-Resolution Coherent Probe Spectroscopy of a Polariton Quantum Fluid.

Characterizing elementary excitations in quantum fluids is essential to study their collective effects. We present an original angle-resolved coherent probe spectroscopy technique to study the dispersion of these excitation modes in a fluid of polaritons under resonant pumping. Thanks to the unprecedented spectral and spatial resolution, we observe directly the low-energy phononic behavior and detect the negative-energy modes, i.