Publications by authors named "A Bozzao"
According to the cortico-striato-thalamo-cortical (CSTC) model of obsessive-compulsive disorder (OCD), the striatum plays a primary role in its neuropathophysiology. Hypothesising that volumetric alterations are more pronounced in subcortical areas of patients within the CSTC circuit compared to healthy controls (HCs), we conducted a coordinate-based meta-analysis of magnetic resonance imaging (MRI) studies. We included 26 whole-brain MRI studies, comprising 3,010 subjects: 1,508 patients (788 men, 720 women; mean age: 30.
View Article and Find Full Text PDFObjectives: To discriminate between post-treatment changes and tumor recurrence in patients affected by glioma undergoing surgery and chemoradiation with a new enhancing lesion is challenging. We aimed to evaluate the role of ASL, DSC, DCE perfusion MRI, and 18F-DOPA PET/CT in distinguishing tumor recurrence from post-treatment changes in patients with glioma.
Materials And Methods: We prospectively enrolled patients with treated glioma (surgery plus chemoradiation) and a new enhancing lesion doubtful for recurrence or post-treatment changes.
Article Synopsis
- Late-life depression (LLD) is a common mental disorder among the elderly, linked to cognitive decline and higher mortality rates, making it a pressing public health concern.
- A meta-analysis reviewed 19 studies involving 844 participants, revealing significant brain activation differences between LLD patients and healthy controls in specific regions related to emotional and cognitive processing.
- The findings highlight altered brain functioning in areas of the cortico-limbic-striatal network in LLD, suggesting potential targets for more effective prevention and treatment strategies.
Contrast enhancement resolution induced by corticosteroids is a phenomenon primarily associated with primary central nervous system lymphoma, while malignant brain gliomas usually maintain a consistent radiological appearance during systemic steroid treatment. Although rare, a few primary and metastatic intracranial lesions have shown similar radiographic changes following corticosteroid therapy. In the case of glioblastomas, corticosteroid therapy is commonly used to alleviate pressure effects from peritumoral edema, but its impact on contrast enhancement is not well-established.
View Article and Find Full Text PDFObjectives: This study proposes a preoperative radiologic scoring system for predicting posterior tympanotomy (PT) and mastoidectomy-associated difficulties during cochlear implantation (CI).
Study Design: It was a prospective case-series study.
Settings: The included CI surgeries were performed at tertiary referral institutions from October 2022 to April 2023.