MELK as a Mediator of Stemness and Metastasis in Aggressive Subtypes of Breast Cancer.

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest prognosis and lacks actionable molecular targets for treatment. Maternal embryonic leucine zipper kinase (MELK) is highly expressed in TNBC and has been implicated in poor clinical outcomes, though its mechanistic role in the aggressive biology of TNBC is poorly understood. Here, we demonstrate a role of MELK in TNBC progression and metastasis.

Large Language Models for Chatbot Health Advice Studies: A Systematic Review.

Importance: There is much interest in the clinical integration of large language models (LLMs) in health care. Many studies have assessed the ability of LLMs to provide health advice, but the quality of their reporting is uncertain.

Objective: To perform a systematic review to examine the reporting variability among peer-reviewed studies evaluating the performance of generative artificial intelligence (AI)-driven chatbots for summarizing evidence and providing health advice to inform the development of the Chatbot Assessment Reporting Tool (CHART).

Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity.

Preterm birth (PTB; delivery before 37 weeks), the main cause of neonatal death worldwide, can lead to adverse neurodevelopmental outcomes, as well as lung and gut pathology. PTB can be associated with ascending vaginal infection. Previously, it was shown that ascending Escherichia coli infection in pregnant mice induces PTB and reduces pup survival.

Carbonyl reductase 1: a novel regulator of blood pressure in Down syndrome.

Approximately one in every 800 children is born with the severe aneuploid condition of Down syndrome (DS), a trisomy of chromosome 21. Low blood pressure (hypotension) is a common condition associated with DS and can have a significant impact on exercise tolerance and quality of life. Little is known about the factors driving this hypotensive phenotype, therefore therapeutic interventions are limited.