Facile Synthesis of SnO₂ Aerogel/Reduced Graphene Oxide Nanocomposites via in Situ Annealing for the Photocatalytic Degradation of Methyl Orange.

SnO₂ aerogel/reduced graphene oxide (rGO) nanocomposites were synthesized using the sol⁻gel method. A homogeneous dispersion of graphene oxide (GO) flakes in a tin precursor solution was captured in a three-dimensional network SnO₂ aerogel matrix and successively underwent supercritical alcohol drying followed by the in situ thermal reduction of GO, resulting in SnO₂ aerogel/rGO nanocomposites. The chemical interaction between aerogel matrix and GO functional groups was confirmed by a peak shift in the Fourier transform infrared spectra and a change in the optical bandgap of the diffuse reflectance spectra.

Polypropylene/Silica Aerogel Composite Incorporating a Conformal Coating of Methyltrimethoxysilane-Based Aerogel.

Silica aerogels possess low thermal conductivity but have a brittle nature, while their polymers tend to exhibit enhanced mechanical properties. In this study, we introduce a new approach to overcoming this brittle property of silica aerogels. Polypropylene/silica aerogel composites were prepared by thermally induced phase separation followed by a supercritical CO₂ drying method.

Flexibility and applicability of β-expectation tolerance interval approach to assess the fitness of purpose of pharmaceutical analytical methods.

An innovative versatile strategy using Total Error has been proposed to decide about the method's validity that controls the risk of accepting an unsuitable assay together with the ability to predict the reliability of future results. This strategy is based on the simultaneous combination of systematic (bias) and random (imprecision) error of analytical methods. Using validation standards, both types of error are combined through the use of a prediction interval or β-expectation tolerance interval.

Usefulness of capability indices in the framework of analytical methods validation.

Analytical methods capability evaluation can be a useful methodology to assess the fitness of purpose of these methods for their future routine application. However, care on how to compute the capability indices have to be made. Indeed, the commonly used formulas to compute capability indices such as Cpk, will highly overestimate the true capability of the methods.

Do placebo based validation standards mimic real batch products behaviour? Case studies.

Analytical methods validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application. Validation usually involves validation standards or quality control samples that are prepared in placebo or reconstituted matrix made of a mixture of all the ingredients composing the drug product except the active substance or the analyte under investigation. However, one of the main concerns that can be made with this approach is that it may lack an important source of variability that come from the manufacturing process.