Development of [Ac]Ac-DOTA-C595 as radioimmunotherapy of pancreatic cancer: in vitro evaluation, dosimetric assessment and detector calibration.

Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy which may benefit from radioimmunotherapy. Previously, [Lu]Lu-DOTA-C595 has been developed as a beta-emitting radioimmunoconjugate to target cancer-specific mucin 1 epitopes (MUC1-CE) overexpressed on PDAC. However, the therapeutic effect may be enhanced by using an alpha-emitting radionuclide such as Actinium-225 (Ac-225).

COMPARATIVE HYGIENIC ASSESSMENT OF THE POTENTIAL DIQUAT HAZARD TO THE POPULATION WHEN CONSUMING AGRICULTURAL CROPS TREATED WITH THE REGLONE AIR 200 SL FORMULATION USING DIFFERENT APPLICATION TECHNOLOGIES (UAV, AERIAL, HIGH-CLEARANCE ROD SPRAYER TREATMENT).

Objective: The aim: Assessment of the hazard to the population when consuming treated crops by using different technologies.

Patients And Methods: Materials and methods: Unmanned aerial vehicle XAG XPlanet 2020 equipped with four rotating rotors, which allows to keep in the air a 20-liter tank was used for spraying field; a manned aircraft AN-2 aggregated with a serial sprayer. High-clearance rod treatment of sunflower and rapeseed crops was carried out by using a PLA MAP II 2010 tractor.

CHANGES IN IMMUNOLOGICAL INDICATORS UNDER THE INFLUENCE OF TREATMENT OF GENERALIZED PERIODONTITIS IN PATIENTS WITH MANIFESTATIONS OF PSYCHOEMOTIONAL STRESS.

Objective: The aim: The aim of investigation was to determine the effect of the proposed treatment of patients with generalized periodontitis and psychoemotional stress on changes in the immune system of patients.

Patients And Methods: Materials and methods: The clinical and laboratory investigations were conducted to revealed the effectiveness of the proposal complex of adrenoblockers in complex treatment of generalized periodontitis in 40 patients with psychoemotional stress. To assess the effectiveness of the treatment, the level of cortisol in saliva was determined.

NEAREST RESULTS OF TREATMENT OF EXACERBATED GENERALIZED PERIODONTITIS IN PATIENTS WITH MANIFESTATIONS OF PSYCHOEMOTIONAL STRESS.

To date, the common etiological factor of periodontal disease is periodontopathogenic microflora. In the case of favorable circumstances (the presence of systemic diseases, reduced general or local resistance), it multiplies rapidly and causes periodontal disease: gingivitis or periodontitis. Among these systemic lesions, psychological stress occupies a significant place.

COMBINED CARIES AND GASTROESOPHAGEAL REFLUX DISEASE.

Caries and its complications take the leading role in the development of gastrointestinal diseases in young people. Gastroesophageal reflux disease is one of the most common diseases of the digestive tract. An important role among the components of the immune defense of the oral cavity belongs to non-specific humoral factors produced by various cells that act in a complex, which increases the final effect of protection.