Publications by authors named "A Bortolami"
Integrin_K Channel_Complexes (IKCs), are implicated in neurodevelopment and cause developmental and epileptic encephalopathy (DEE) through mechanisms that were poorly understood. Here, we investigate the function of neocortical IKCs formed by voltage-gated potassium (Kv) channels Kcnb1 and α5β5 integrin dimers in wild-type (WT) and homozygous knock-in (KI) Kcnb1 mouse model of DEE. Kcnb1 mice suffer from severe cognitive deficit and compulsive behavior.
View Article and Find Full Text PDFAmong flaviviruses, Zika virus (ZIKV) is the only arbovirus officially recognized as a teratogenic agent, as a consequence of its ability to infect and cross the placental barrier causing congenital malformation in the fetus. While many studies have focused on understanding ZIKV pathogenesis during pregnancy, the viral mechanisms affecting fetal development remain largely unclear. In this study, we investigated ZIKV virulence in placental trophoblasts, using viruses with distinct lipid profiles.
View Article and Find Full Text PDFArticle Synopsis
- The study monitored the circulation of Influenza A virus (AIV) in wild ducks and birds in Lombardy from 2022-2024, analyzing samples collected from hunting and dead birds using real-time RT-PCR and whole genome sequencing.
- Out of 3,497 hunted ducks, 184 tested positive for AIV, revealing 21 different subtypes, with H5N1 HPAIV being the most common during winter 2022-2023.
- In surveys of dead wild birds, notably buzzards and gulls, two buzzards and one grey heron tested positive for H5N1, while gulls showed a significant increase in positivity from 0% in 2022 to 51%
The neurons of the melanocortin system regulate feeding and energy homeostasis through a combination of electrical and endocrine mechanisms. However, the molecular basis for this functional heterogeneity is poorly understood. Here, a voltage-gated potassium (Kv) channel named KCNB1 (alias Kv2.
View Article and Find Full Text PDFPurpose: To investigate the 90° change of direction (COD) task in an extensive cohort of competitive healthy football players within the CUTtheACL study and to provide normative values and differences between males and females for full-body kinematics based on two-dimensional (2D) video analysis and scoring system.
Methods: One-thousand-and-two competitive football (soccer) players (age 16.3 ± 2.