Publications by authors named "A Borodovsky"
Article Synopsis
- IgA nephropathy is a common kidney disease characterized by proteinuria, which signals a risk of kidney failure, and complement activation contributes to its progression.
- Cemdisiran, an experimental treatment that inhibits the production of a specific complement protein (C5), was evaluated in a study involving adults with IgA nephropathy to see if it could reduce proteinuria.
- The results showed that cemdisiran significantly reduced protein levels in urine and blood levels of C5, with mostly mild side effects, suggesting it may be a promising therapy for managing IgA nephropathy.
Complement dysregulation underpins the physiopathology of paroxysmal nocturnal hemoglobinuria (PNH). Cemdisiran, an RNA interference investigational treatment, silences complement component 5 (C5) expression in the liver. Previously reported results showed sustained reduction in C5 levels following cemdisiran monotherapy, with >90% reduction in patients with PNH.
View Article and Find Full Text PDFMembranous nephropathy (MN) is an antibody-mediated autoimmune disease characterized by glomerular immune complexes containing complement components. However, both the initiation pathways and the pathogenic significance of complement activation in MN are poorly understood. Here, we show that components from all three complement pathways (alternative, classical and lectin) are found in renal biopsies from patients with MN.
View Article and Find Full Text PDFArticle Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease linked to uncontrolled complement activation, and current treatments target this process with terminal complement inhibition.
- This study evaluated the effectiveness of combining cemdisiran, an RNAi therapy that reduces C5 production, and pozelimab, a monoclonal antibody against C5, in non-human primates.
- Results showed that the combination therapy provided longer-lasting and more effective inhibition of complement activity compared to each treatment used alone, suggesting its potential as a long-term treatment option for PNH.