Metastatic renal cell carcinoma simulating glomus jugulare tumor.

A 59-year-old man presented with jugular foramen syndrome caused by a mass with roentgenographic and histologic features highly suggestive of a glomus jugulare tumor. However, electron microscopic examination of the surgical specimen revealed features diagnostic of a previously unsuspected renal cell carcinoma. Because primary tumors of the glomus jugulare and metastatic renal cell carcinoma may present with the same clinical and roentgenographic findings and look similar histologically, careful electron microscopic examination of the tumor and urologic screening should be performed in suspected cases of glomus jugulare tumors.

High dose Ara-C related leukoencephalopathy.

Two patients with acute myelomonocytic leukemia in central nervous system relapse developed clinical signs and computerized tomographic evidence of leukoencephalopathy five to seven days after intravenous high dose Ara-C therapy. The first patient had received 30 gm of intravenous Ara-C with cranial irradiation (1680 rad in 2 fractions) and intrathecal Ara-C (100 mg X twice) for an intracerebral chloroma and leptomeningeal leukemia. In this patient the leukoencephatlopathy was probably a result of a synergistic effect of the concomitant triple therapy.

Central neural antigens: detection and diagnostic application.

During the last few years, methods have been developed which permit practical use of biochemical research on the nervous system. In the central nervous system, proteins have been identified for astrocytes (glial fibrillary acidic protein and vimentin) and oligodendroglia (myelin basic protein and other glycoproteins). For certain classes of nerve cells, the neurofilament proteins and neuron-specific enolase (a glycolytic isoenzyme) have been identified.

The endocrine glands in Pompe's disease. Report of two cases.

Pompe's disease (type II glycogenosis), an infantile form of generalized glycogenosis, is characterized biochemically by deficiency of lysosomal acid alpha-1,4-glucosidase and morphologically by intralysosomal glycogen storage in multiple organs, notably the central nervous system, heart, liver, and skeletal muscles. The endocrine system has not been described in detail in the literature. In two infants with Pompe's disease, intralysosomal glycogen was identified in the adrenal cortex and medulla, thyroid gland, parathyroid glands, pancreatic islets, and pituitary gland.

A rabbit model of intracerebral hematoma.

The epiphenomena that seem to cause deterioration and death after spontaneous interacerebral hematoma (SICH) might best be studied in an animal model. Therefore, the principles for developing such a model and techniques to study these phenomena were evaluated. Animals will tolerate injection of 3%-5% of their brain volume with a high proportion of clots.