Publications by authors named "A Bonura"
Background: Direct Oral Anticoagulants (DOACs) have revolutionized the management of thrombotic conditions, providing more predictable and manageable anticoagulation compared to traditional vitamin K antagonists. Despite their success, major bleeding events remain a significant concern. This study aims to assess and compare the haemorrhagic risks associated with various DOACs using data from the FDA's Adverse Event Reporting System (FAERS).
View Article and Find Full Text PDFBackground/objectives: Driving abilities require the synchronized activity of cerebral networks associated with sensorimotor integration, motricity, and executive functions. Drivers with Parkinson's disease (DwP) have impaired driving ability, but little is known about the impact of "wearing-off" and therapies in addition to L-DOPA on driving capacities. This study aimed to (i) compare driving performance between DwP during different motor states and healthy controls and (ii) assess the impact of add-on therapies on driving abilities.
View Article and Find Full Text PDFBackground: Arterial dissection, a condition marked by the tearing of the carotid artery's inner layers, can result in varied clinical outcomes, including progression, stability, or spontaneous regression. Understanding these outcomes' underlying mechanisms is crucial for enhancing patient care, particularly with the increasing use of computer simulations in medical diagnostics and treatment planning. The aim of this study is to utilize computational analysis of blood flow and vascular wall to: (1) understand the pathophysiology of stroke-like episodes in patients with carotid artery dissection; and (2) assess the effectiveness of this method in predicting the evolution of carotid dissection.
View Article and Find Full Text PDFArticle Synopsis
- Headache disorders like migraine and tension-type headaches are often underdiagnosed and undertreated, despite advancements in targeted medications; NSAIDs and analgesics are still the most commonly used treatments.
- A study conducted in 2022 at a tertiary headache center tracked 283 migraine patients, revealing that NSAID use decreased over three months while triptan use increased, indicating a shift in treatment strategies.
- Results showed that adding prophylactic therapies like topiramate or amitriptyline was linked to reduced NSAID intake and headache frequency, highlighting the need for tailored treatment plans in managing headaches effectively.
Article Synopsis
- - Argyria is a condition caused by the chronic buildup of silver in various body tissues, including the skin, liver, and brain, and its connection to neuropsychiatric issues is still under discussion.
- - The authors conducted a narrative review of case reports to explore the relationship between silver accumulation and neurological or psychiatric symptoms, highlighting a case of a man who developed severe depression after using a silver nasal spray.
- - They identified 15 cases where patients with argyria displayed symptoms like epilepsy, neurodegenerative diseases, and psychiatric disorders, emphasizing the importance of understanding the mechanisms and symptoms to prevent potential brain complications.