Publications by authors named "A Bondi"
This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility, limiting its bio-distribution and therapeutic efficacy. The potential of nutlin-3a-loaded ethosomes was investigated on two in vitro models of melanoma: the HT144 cell line p53 and the SK-MEL-28 cell line p53. Nutlin-3a-loaded ethosomes were characterized for their physicochemical properties and used to treat melanoma cells at different concentrations, considering nutlin-3a solution and empty ethosomes as controls.
View Article and Find Full Text PDFArticle Synopsis
- The study monitored 29 Maquet heater-cooler units (HCUs) over a 63-month period to track the presence of non-tuberculous mycobacteria (NTM) in response to the replacement of LivaNova devices due to contamination concerns.
- Results showed a significant increase in NTM positivity, particularly after three years, with 100% of HCU40 and 62% of HU35 devices colonized, primarily by Mycobacterium gordonae.
- The findings indicate that current disinfection methods using chloramine-T are insufficient, highlighting the need for improved device safety designs and new disinfection protocols.
Article Synopsis
- - The QCMV test measures immune response to cytomegalovirus (CMV) in lung transplant patients by detecting IFN-γ from CD8+ T cells, helping to assess the risk of CMV-related complications and lung rejection.
- - In a study of 73 lung transplant patients, those with no immunity to CMV (group C) had a lower incidence of acute rejection events (AR) compared to those who were at high risk for CMV (group D), who also had more viral replication.
- - The research found that non-reactive QCMV patients (group B) faced a significantly higher risk of developing chronic lung allograft dysfunction (CLAD) over 24 months, suggesting the
Article Synopsis
- Streptococcus pneumoniae
- in Piedmont, Italy.
- * Data from 2008 to present showed that out of 2,076 strains collected, 21.9% were resistant to penicillin G and 40.3% to erythromycin, with an overall increased risk of penicillin-resistant infections across all age groups.
- * The findings indicate a significant rise in penicillin G-resistant pneumococcal disease particularly among infants and the elderly following vaccination implementation, while the SARS-CoV2 pandemic didn't show a significant impact on AMR
Recently, a large number of nosocomial infections have been caused by an emerging pathogen that is rising as a worldwide issue in human health: . This yeast is considered resistant to antifungals of the first-line therapies, and consequently it is related to morbidity and mortality. Therefore, the aim of this research was to determine the in vitro anti- activity against twenty-three resistant clinical strains of different essential oils (EOs), pure or in combination with traditional antifungal agents, mainly caspofungin, fluconazole, micafungin and 5-flucytosine.
View Article and Find Full Text PDF