Publications by authors named "A Bohannon"
This report describes how stakeholder groups informed a web-based care planning tool's development for addressing root causes of poor health. Stakeholders included community members (n = 6), researchers (n = 6), community care providers (n = 9), and patients (n = 17). Feedback was solicited through focus groups, semi-structured interviews, and user experience observations and then qualitatively analyzed to identify themes.
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- PGC-1α deficiency is linked to various neurological and psychiatric disorders and is vital for neurotransmitter release, axonal integrity, and neuronal metabolism.
- The study identified the estrogen-related receptor (ERR) family, particularly ERRα, as key transcription factors influencing PGC-1α-dependent gene expression in the brain.
- Data from knockout models showed that while ERRα is essential for regulating certain PGC-1α-dependent genes, other factors likely contribute to their overall expression in neurons.
Although dexterity relies on the constant transmission of sensory information, unchecked feedback can be disruptive. Yet how somatosensory feedback from the hands is regulated and whether this modulation influences movement remain unclear. We found that mouse tactile afferents recruit neurons in the brainstem cuneate nucleus, whose activity is modulated by distinct classes of local inhibitory neurons.
View Article and Find Full Text PDFBackground: Genomic analysis is essential for risk stratification in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a potential replacement for conventional cytogenetic and sequencing approaches, but its accuracy, feasibility, and clinical utility have not been demonstrated.
Methods: We used a streamlined whole-genome sequencing approach to obtain genomic profiles for 263 patients with myeloid cancers, including 235 patients who had undergone successful cytogenetic analysis.