Publications by authors named "A Bober"
Article Synopsis
- Obesity is characterized as a low-grade inflammatory disease linked to conditions like diabetes and chronic pain, with chemokines contributing to inflammation and hypersensitivity.
- Research highlights the involvement of specific chemokine receptors (CCR2 and CCR5) and their ligands in pain and obesity in both animal models and human patients.
- Blocking these receptors can reduce chronic pain sensitivity, indicating that targeting these pathways may offer therapeutic options for managing conditions related to obesity and diabetes.
Objectives: The study aimed to assess the occurrence of body posture disorders and their changes under the influence of a physioprophylactic program in children depending on body weight.
Methods: In the examined children, the general and segmental body composition and body posture were determined using a physiotherapeutic assessment based on the Kasperczyk method. Mass, overall, and segmental body composition were determined using the bioelectrical impedance method using a TANITA body composition analyzer.
The ligands of chemokine receptors 2 and 5 (CCR2 and CCR5, respectively) are associated with the pathomechanism of neuropathic pain development, but their role in painful diabetic neuropathy remains unclear. Therefore, the aim of our study was to examine the function of these factors in the hypersensitivity accompanying diabetes. Additionally, we analyzed the analgesic effect of cenicriviroc (CVC), a dual CCR2/CCR5 antagonist, and its influence on the effectiveness of morphine.
View Article and Find Full Text PDFBACKGROUND The human foot has a complex structure and the ligamentous and muscular apparatus undergoes transformation and adaptation during its ontogenetic development. Excessive body mass may be one of the factors disrupting proper foot formation. This study aimed to assess the foot structure in preschool children in relation to body mass.
View Article and Find Full Text PDFPurpose: To derive a Delphi method-based consensus for the surgical management of Full Thickness Macular Hole (FTMH) and Lamellar Macular Hole (LMH).
Methods: 37 expert VR surgeons from 21 mainly European countries participated in Delphi method-based questionnaire for diagnosis and treatment of FTMHs and LMHs.
Results: A total of 36 items were rated in round 1 by 37 participants, of which 10 items achieved consensus: intraoperative verification of PVD; clinical superiority of OCT-based FTMH classification; practical ineffectiveness of ocriplasmin; circular 360° ILM peeling for small macular holes; use of regular surgical technique for the size of the hole in concomitant retinal detachment; performing complete vitrectomy; SF6 gas as preferred tamponade; cataract surgery if crystalline lens is mildly/moderately opaque; removal of both ILM and LHEP in LMH surgery.