Publications by authors named "A Blomquist"
Article Synopsis
- Aspergillus fumigatus is a common fungus found in the lungs of cystic fibrosis patients, and this study aimed to explore its impact on lung function, identify risk factors for colonization, and assess treatments for asymptomatic cases.
- Data was collected from a CF registry between 2014-2018, showing that 14.6% of patients became colonized, with inhaled antibiotics linked to higher colonization rates, but no significant decline in lung function was noted for colonized patients.
- Treatment of asymptomatic A. fumigatus did not show clear benefits, as those who received antifungal therapy experienced a more significant decline in lung function compared to untreated individuals.
Objectives: Flotation-REST is a treatment for deep relaxation, where a person is contained in a stimuli-restricted environment and floats in water with high salt content. The aim was to investigate the effects from flotation-REST on people with insomnia diagnosis, as previous studies of flotation-REST have demonstrated some effects on sleep but have limitations regarding sample selections and sleep measures.
Material And Methods: Six participants were recruited through an outpatient psychiatry clinic and posters on a university campus.
Rho GTPases are implicated in a multitude of cellular processes regulated by membrane receptors, such as cytoskeletal rearrangements, gene transcription and cell growth and motility. Activation of these GTPases is under the direct control of guanine nucleotide exchange factors (GEFs), the Dbl family proteins. By searching protein databases we have identified a novel Rho-GEF, termed p114-Rho-GEF, which similarly to other Rho-GEFs contains a Dbl homology domain followed by a pleckstrin homology domain.
View Article and Find Full Text PDFSeveral guanine nucleotide exchange factors (GEFs) for Rho-GTPases have been identified, all of them containing a Dbl homology (DH) and pleckstrin homology (PH) domain, but exhibiting different specificities to the Rho family members, Rho, Rac and Cdc42. We report here that KIAA0380, a protein with a tandem DH/PH domain, an amino-terminal PDZ domain and a regulator of G protein signalling (RGS) homology domain, is a specific GEF for RhoA, but not for Rac1 and Cdc42, as determined by GDP release, guanosine 5'-O-(3-thio)triphosphate (GTPgammaS) binding and protein binding assays. When expressed in J82 cells, DH/PH domain-containing forms of KIAA0380 induced actin stress fibers, whereas expression of the RGS homology domain prevented lysophosphatidic acid (LPA)-induced stress fiber formation.
View Article and Find Full Text PDF