Publications by authors named "A Bleckmann"
Background And Objective: The standard first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor () mutations or anaplastic lymphoma kinase () fusions is targeted therapy using tyrosine kinase inhibitors (TKIs). However, data are still lacking on the use of TKIs as a neoadjuvant or induction approach. Therefore, this narrative review aims to summarize the current knowledge on resectable -mutant and -fused NSCLC regarding available perioperative treatment regimens and off-label neoadjuvant use of targeted therapy.
View Article and Find Full Text PDFBackground/aim: Biomarkers for patients suffering from glioblastoma (GBM) are scarce. Extracellular vesicles (EV) are a promising candidate for a potential biomarker. Therefore, EV concentration could be a potential biomarker of tumor burden, volume, and prognosis.
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- Preclinical studies suggest that combining MEK inhibition with autophagy or CDK4/6 targeting may be beneficial for pancreatic cancer (PDAC) patients.
- A retrospective analysis of 34 patients treated with trametinib combined with hydroxychloroquine (THCQ) or palbociclib (TP) was conducted to evaluate the effectiveness of these regimens.
- Results showed that both combinations were ineffective, with most patients experiencing disease progression within a short time frame, highlighting the need for better treatment strategies for advanced PDAC with specific genetic mutations.
Article Synopsis
- Circulating tumor cells and liquid biopsy markers could significantly influence cancer treatment decisions in the future.
- This study compares two reverse transcription enzymes, SuperScript IV VILO and Sensiscript, focusing on their effectiveness in detecting biomarkers in prostate cancer cell lines and clinical liquid biopsy samples.
- Results show that VILO outperforms SS, leading to more patients being correctly identified as biomarker-positive, which is crucial for effective clinical monitoring and treatment decisions.