Publications by authors named "A Biscontin"
Background: The Antarctic krill Euphausia superba is a keystone species in the Southern Ocean ecosystem. This crustacean has an ancestral clock whose main components have been identified and characterized in the past few years. However, the second feedback loop, modulating clock gene expression through two transcription factors, VRI and PDP1, has yet to be described.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how deep learning (DL) can enhance the classification of retinal diseases using OCT images, but faces challenges like variability in conditions and noise in the images.
- The research evaluated the performance of five DL architectures (ResNet18, ResNet34, ResNet50, VGG16, and InceptionV3) on a dataset of 5526 images, focusing on both data scarcity and label accuracy.
- Results showed that with 345 or more training images, DL models can accurately classify retinal pathologies, but labeling errors significantly impair performance, necessitating more training images to offset these errors.
The present study aimed to develop a TaqMan genotyping card for molecular chronotype assessment based on a predictive panel of 35 previously identified genetic variants. A reliable TaqMan assay was successfully developed for 33 out of the 35 chronotype-predictive variants. The resulting TaqMan genotyping card was utilized to genetically characterize 196 new individuals (in addition to the previously studied 96) and the Morningness-Eveningness Questionnaire was utilized for their phenotypical chronotype assessment.
View Article and Find Full Text PDFThe human circadian timing system depends on the light/dark cycle as its main cue to synchronize with the environment, and thus with . However, human activities depend also on , i.e.
View Article and Find Full Text PDFIntroduction: The Coronavirus Disease 2019 (COVID-19) is mainly a respiratory syndrome that can affect multiple organ systems, causing a variety of symptoms. Among the most common and characteristic symptoms are deficits in smell and taste perception, which may last for weeks/months after COVID-19 diagnosis owing to mechanisms that are not fully elucidated.
Methods: In order to identify the determinants of olfactory symptom persistence, we obtained olfactory mucosa (OM) from 21 subjects, grouped according to clinical criteria: i) with persistent olfactory symptoms; ii) with transient olfactory symptoms; iii) without olfactory symptoms; and iv) non-COVID-19 controls.