Publications by authors named "A Bilotta"
The growing importance of state assessments in civil engineering has led to intensive research into the development of damage identification methods based on vibrations. Natural frequencies and modal shapes have garnered great interest because modal parameters are invariant of structure. Moreover, thanks to the global nature of modal parameters, their variations are not limited to the location of the damage.
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- The study aimed to explore the impact of socioeconomic status (SES) on the progression and outcomes of upper tract urothelial carcinoma (UTUC) in patients.
- The research involved classifying 432 patients undergoing surgery for UTUC into "advantaged" and "disadvantaged" groups based on their area deprivation index (ADI), with comparisons made on treatment and survival outcomes.
- Findings indicated no significant differences in tumor characteristics, recurrence-free survival (RFS), or overall survival (OS) between SES groups, suggesting improved healthcare access and management strategies may benefit disadvantaged patients.
Hereditary breast cancer accounts for 5-10% of all cases, with pathogenic variants in and other susceptibility genes playing a crucial role. This study elucidates the prevalence and spectrum of germline variants in 13 cancer predisposition genes among high-risk hereditary breast cancer patients from Southern Italy. We employed next-generation sequencing (NGS) to analyze 254 individuals selected through genetic counseling.
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- GPR120 has been linked to anti-inflammatory processes and this study explores its role in regulating neutrophil functions against gut bacteria.
- Wild-type (WT) mice and GPR120-deficient mice were used to analyze microbiota differences, inflammation severity, and neutrophil capabilities during infections and colitis models.
- The study found that GPR120 promotes neutrophils to produce reactive oxygen species (ROS) and extracellular traps (NETs), enhancing their ability to combat bacteria, suggesting that GPR120 is crucial for protecting against bacterial infections in the gut.
Background & Aims: Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood.
Methods: In this study, T-cell transfer model with wild-type (WT) and Areg Th17 cells and dextran sulfate sodium (DSS)-induced chronic colitis model in WT and Areg mice were used.